Table 5.
GREML-SC and GREML-LDMS estimates using the ACCORD genotype and imputed data, respectively
| Phenotype | Proportion of cases in the sample | n | V(G)/V(p) (SE) | |
|---|---|---|---|---|
| GREML-SC | GREML-LDMS | |||
| Retin1 | 0.084 | 4,318 | 0.139 (0.088) | 0.288 (0.183) |
| Retin2 | 0.158 | 4,318 | 0.044 (0.083) | 0.063 (0.169) |
| Retin3 | 0.360 | 4,318 | 0.002 (0.084) | NA |
| Retin4 | 0.068 | 4,318 | 0.000 (0.089) | 0.328 (0.174) |
| Neph1 | 0.591 | 4,318 | 0.123 (0.090) | NA |
| Neph2 | 0.070 | 3,866 | 0.106 (0.101) | 0.409 (0.201) |
| Neph3 | 0.028 | 4,318 | 0.000 (0.082) | NA |
| Neph4 | 0.616 | 4,318 | 0.129 (0.091) | NA |
| Neph5 | 0.241 | 2,912 | 0.160 (0.132) | 0.596 (0.254) |
| Primary | 0.106 | 4,318 | 0.248 (0.093) | NA |
| Nonfatal MI | 0.071 | 4,318 | 0.102 (0.090) | 0.110 (0.192) |
| Major CHD | 0.129 | 4,318 | 0.090 (0.089) | 0.118 (0.181) |
| Total mortality | 0.066 | 4,318 | 0.013 (0.088) | NA |
| CVD mortality | 0.028 | 4,318 | 0.094 (0.089) | NA |
| Nonfatal stroke | 0.015 | 4,318 | 0.112 (0.090) | NA |
| Total stroke | 0.018 | 4,318 | 0.179 (0.091) | NA |
NA under GREML-LDMS, the GREML analysis failed to run due to the small sample size; n, number of samples without missing phenotype; V(G)/V(p), proportion of phenotypic variance explained by genotypes (i.e., heritability, as observed in the study population).