Figure 1.

Somatic mutations in HPV(+) OPSCC

Center panel: Waterfall plot of somatic mutations for each patient. Each row represents an individual recurrently mutated gene, and each column represents a patient. Mutated genes are ranked from most frequently mutated (top) to the least (bottom). Colored boxes indicate mutated genes, with colors corresponding to mutational consequences. Black circles or triangles represent the number of changes (amplifications or deletions, respectively, with log2 ratio greater than +/− 0.5) at each locus. Top panel: mutational frequency is displayed for each patient, representing the total number of nonsynonymous single nucleotide variations after filtration. Left panel: mutated genes are annotated by the mutational significance classifiers used in the study. Right panel: the frequency of mutations in each gene as a proportion of the total cohort size. Bottom panel: Clinical annotation for each patient.