Figure 2.

Tobacco exposure is associated with differences in trinucleotide substitution classes

(A) Consistent with previous reports, mutations in our cohort predominantly consisted of C > T transitions and C > G transversions.

(B–G) Each class of nucleotide substitution is displayed as a proportion of total mutations.

(F) Tobacco exposed tumors demonstrated a 2.3-fold greater median proportion of T > C transitions compared with tumors of never tobacco users (∗ Wilcoxon p < 0.05 and FDR <0.1, ns = not significant).