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. 2022 Apr 6;25(5):104216. doi: 10.1016/j.isci.2022.104216

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Aging and APOBEC-related mutational signatures are dominant in HPV(+) OPSCC but account for a lower proportion of mutations in tobacco users

(A) Heatmap of mutational signatures demonstrates the dominance of signatures #1 (Aging-related), #2 and 13 (both APOBEC-related) in HPV(+) OPSCC. Despite high reported rates of tobacco use in the cohort, mutations attributable to tobacco-related signatures #4 and #29 were absent.

(B) The proportion of signature #1, #2, and #13 mutations is significantly greater in never tobacco users, whereas (C) the proportion of uncategorized mutations is significantly greater in those reporting current or former tobacco use (∗ Wilcoxon p < 0.05).