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. 2022 Apr 6;25(5):104216. doi: 10.1016/j.isci.2022.104216

Figure 5.

Figure 5

Tobacco use at the time of diagnosis is associated with decreased T cell infiltration of the primary TIME

(A) Heatmap displaying the TGEP transcript expression for each patient. Patients are ranked from high (top) to low (bottom) based on their TGEP scores.

(B) TGEP scores were significantly associated with CD8+ IHC staining (Spearman Rho = 0.728, p < 0.001).

(C) TGEP scores differ significantly by tobacco use, with current tobacco users having the lowest scores (∗ Kruskal–Wallis p < 0.05).

(D) Tobacco history reveals differences in TGEP scores (high vs. low) and mutational frequency (high vs. low) by tobacco use groups (Fisher’s exact p < 0.05).

(E) In never tobacco users, there was a significant positive correlation between TGEP scores and mutational frequency. This correlation was not present in current or former tobacco users (∗∗ Spearman p < 0.01).