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. 2022 Apr 6;25(5):104216. doi: 10.1016/j.isci.2022.104216

Table 1.

Demographic and clinical characteristics of the study cohort

Current
Former
Never
p value Total
(N = 9) (N = 19) (N = 19) (N = 47)
Age at diagnosis

Mean (SD) 57.6 (5.22) 61.3 (10.6) 56.9 (9.07) 0.312 58.8 (9.26)

Decade of diagnosis

50–59 6 (66.7%) 7 (36.8%) 7 (36.8%) 0.212 20 (42.6%)
60–69 3 (33.3%) 5 (26.3%) 4 (21.1%) 12 (25.5%)
40–49 0 (0%) 2 (10.5%) 6 (31.6%) 8 (17.0%)
70–79 0 (0%) 5 (26.3%) 2 (10.5%) 7 (14.9%)

Gender

Female 1 (11.1%) 3 (15.8%) 1 (5.3%) 0.828 5 (10.6%)
Male 8 (88.9%) 16 (84.2%) 18 (94.7%) 42 (89.4%)

Race/Ethnicity

Asian 0 (0%) 1 (5.3%) 0 (0%) 1 1 (2.1%)
Caucasian 9 (100%) 18 (94.7%) 19 (100%) 46 (97.9%)

Primary tumor subsite

Base of Tongue 3 (33.3%) 9 (47.4%) 8 (42.1%) 0.838 20 (42.6%)
Tonsil 6 (66.7%) 9 (47.4%) 11 (57.9%) 26 (55.3%)
Overlapping Sites 0 (0%) 1 (5.3%) 0 (0%) 1 (2.1%)

Clinical T stage

T0 1 (11.1%) 2 (10.5%) 0 (0%) 0.462 3 (6.4%)
T1 2 (22.2%) 4 (21.1%) 3 (15.8%) 9 (19.1%)
T2 2 (22.2%) 7 (36.8%) 12 (63.2%) 21 (44.7%)
T3 3 (33.3%) 3 (15.8%) 3 (15.8%) 9 (19.1%)
T4 1 (11.1%) 3 (15.8%) 1 (5.3%) 5 (10.6%)

Clinical N stage

N0 1 (11.1%) 2 (10.5%) 0 (0%) 0.166 3 (6.4%)
N1 4 (44.4%) 5 (26.3%) 10 (52.6%) 19 (40.4%)
N2 3 (33.3%) 12 (63.2%) 7 (36.8%) 22 (46.8%)
N3 1 (11.1%) 0 (0%) 2 (10.5%) 3 (6.4%)

Clinical M stage

M0 9 (100%) 18 (94.7%) 19 (100%) 1 46 (97.9%)
M1 0 (0%) 1 (5.3%) 0 (0%) 1 (2.1%)

Overall clinical stage

I 3 (33.3%) 4 (21.1%) 8 (42.1%) 0.658 15 (31.9%)
II 4 (44.4%) 12 (63.2%) 8 (42.1%) 24 (51.1%)
III 2 (22.2%) 2 (10.5%) 3 (15.8%) 7 (14.9%)
IV 0 (0%) 1 (5.3%) 0 (0%) 1 (2.1%)

All patients were p16(+) and had untreated primary OPSCC.