TABLE 1.

Biochemical characteristics of plasma after administration of multiple intravenous doses of Doc-AmB and ABLC to regular diet-fed and cholesterol-fed rabbits^a

Experimental group and drug	Plasma creatinine level			Total plasma Cc (mg/dl)	TRL-Cc (mg/dl)	LDL-Cc (mg/dl)	HDL-Cc (mg/dl)
	With regard to drug administration (μmol/liter)		% Change from baseline level
	Prior to first doseb	5 min after last dosec
Regular diet
Doc-AmB	93 ± 11	252 ± 152	+171	108 ± 22	13 ± 3	44 ± 18	42 ± 1
ABLC	91 ± 11	95 ± 15d	+4.4	67 ± 8d	17 ± 3	25 ± 5	25 ± 6d
Cholesterol-enriched diet
Doc-AmB	125 ± 36	230 ± 160	+84	891 ± 199e	667 ± 172e	181 ± 35e	34 ± 4
ABLC	111 ± 19	141 ± 44	+27	734 ± 249e	628 ± 234e	81 ± 14de	24 ± 7

^aBy these regimens the animals each received 1 mg of AmB per kg. The cholesterol enrichment contained 0.5% (wt/vol) cholesterol. Data are expressed as means ± standard deviations (n = 5 for ABLC for rabbits on a cholesterol-fed diet and n = 4 for all other treatment groups). Total plasma C, total plasma cholesterol levels; TRL-C, triglyceride-rich lipoprotein level (which includes VLDL and chylomicrons); LDL-C, LDL cholesterol level; HDL-C, HDL cholesterol level. 

^bPlasma creatinine levels prior to administration of the first Doc-AmB or ABLC dose and 7 days after regular or cholesterol-enriched diet. 

^cRefers to 5 min following administration of the last dose on day 7. 

^dP < 0.05 versus Doc-AmB treatment. 

^eP < 0.05 versus rabbits fed regular diet.