TABLE 3.

Distribution of AmpB in tissue following 7 consecutive days of Doc-AmB and ABLC administration to control and cholesterol-fed rabbits^a

Tissue	AmB distribution (μg of AmB/g of tissue)
	Control rabbits		Cholestrol-fed rabbits
	Doc-AmB	ABLC	Doc-AmB	ABLC
Kidney	3.95 ± 1.24	0.20 ± 0.12b	5.43 ± 2.41	0.43 ± 0.18bc
Liver	9.27 ± 2.18	8.68 ± 3.20	9.03 ± 1.82	5.12 ± 2.71
Lung	3.22 ± 2.94	1.07 ± 1.30	1.11 ± 0.68	2.77 ± 1.55
Spleen	1.31 ± 0.79	5.37 ± 3.75	3.68 ± 3.10	4.69 ± 3.57
Heart	0.11 ± 0.20	NDd	0.25 ± 0.06	0.02 ± 0.00c

^aBy these regimens the animals each received 1 mg of AmB per kg. The cholesterol enrichment containes 0.5% (wt/vol) cholesterol. Data are means ± standard deviations (n = 4 for Doc-AmB and n = 5 for ABLC). 

^bP < 0.05 versus Doc-AmB. 

^cP < 0.05 versus control rabbits. 

^dND, below detectable limit of the assay.