Fig. 1. Representation of SARS-CoV-2 PLpro in the cartoon representation (PDB: 7JRN). The protein contains the ubiquitin-like (UBL) (purple), thumb (blue), palm (orange red), and finger (green) domains. In the putative site, BL2 loop (Salmon) with key residues Y268 and Q269. The GRL0617 (sick, violet). The bound Zn²⁺ ion in the finger domain is shown as a blue sphere coordinated with C192, C224 and C226.