A few of the potent 4-thiazolidinone derivatives with the respective diseases and target enzyme.

Sl	Compound	Targeting enzyme	Disease/therapeutic use
1		Inhibition of oxidation of tricarboxylic acid cycle substrates such as, α-ketogluterate, citrate, pyruvate and β-hydroxybutyrate30	Epilepsy
2		Tyrosine phosphatase B45	Tuberculosis
3		Metalloproteinase (MMP-13)46	Osteoarthritis
4		E. coli glycosyltransferase MurG and the C. albicans protein mannosyltransferase1 (PMT1)47	Human African trypanosomiasis (HAT)
5		HIV	Reverse transcriptase (RT)27