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. Author manuscript; available in PMC: 2022 Apr 27.
Published in final edited form as: J Mol Biol. 2021 Oct 8;433(23):167295. doi: 10.1016/j.jmb.2021.167295

Figure 1. Mavacamten and Para-nitroblebbistatin inhibit Basal, Actin-Activated, and Myofibrillar Myosin ATPase activities.

Figure 1.

(A) Basal, (B) Actin-activated, and (C) Myofibrillar ATPase activity. All values are presented in the absolute scale (s−1). BcSTF refers to bovine cardiac synthetic thick filaments, and BcMF refers to bovine cardiac myofibrils. Circles and triangles correspond to mavacamten and para-nitroblebbistatin, respectively. Concentrations of these molecules required to attain half-maximal inhibition (IC50) in the ATPase activity are listed in Table 1. Data are expressed as mean ± SEM (n=8 from two experiments that used single preparation of the same reagent purification).