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. Author manuscript; available in PMC: 2022 Apr 27.
Published in final edited form as: J Mol Biol. 2021 Oct 8;433(23):167295. doi: 10.1016/j.jmb.2021.167295

Figure 5. Rigid-body Modelling Using the SAXS data Suggests Conformational Heterogeneity and a Higher Propensity for Conformations Closer To the Closed Head Configuration in Mavacamten-treated HMM.

Figure 5.

Closed head (A) open head (B) conformation with the 25-hep tail and the GFP used for fitting against SAXS data obtained on untreated (DMSO), para-nitroblebbistatin, and mavacamten treated HMM using CRYSOL [47]. χ2 values from CRYSOL indicated. Rigid body models obtained using SASREF [48] performed using open and closed head conformations, respectively, as starting models for HMM treated with (C) DMSO, (D) Para-nitroblebbistatin, and (E) Mavacamten. χ2 values from SASREF analysis are presented under the corresponding models.