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. Author manuscript; available in PMC: 2022 Apr 27.
Published in final edited form as: J Mol Biol. 2021 Oct 8;433(23):167295. doi: 10.1016/j.jmb.2021.167295

Figure 6. Inhibition of Myosin ATPase Caused by Mavacamten, but not Para - nitroblebbistatin, Linearly Correlates with Increase in Myosin SRX Population.

Figure 6.

Correlation plot between myosin SRX population and (A) basal myosin ATPase activity and (B) actin-activated ATPase activity for mavacamten (circles) and para-nitroblebbistatin (triangles). Regression analysis showed a strong linear correlation between myosin population in SRX state and ATPase activity for mavacamten (R2≥0.94) but not for para-nitroblebbistatin-treated samples. All data were normalized by the DMSO-treated sample data and presented as mean±SEM (n≥8 from two experiments that used single preparation of the same reagent purification).