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. 2021 Dec 7;11(62):39058–39086. doi: 10.1039/d1ra05955f

Copper-based nano-catalyst catalyzed protocol for the synthesis of 5-substituted tetrazole containing scaffolds via [3+2] cycloaddition reaction.

graphic file with name d1ra05955f-u5.jpg
Entry Catalyst Solvent Catalyst loading Temperature (°C) Time (h) Yield (%) Ref.
1 Cu(ii)/Fe3O4@APTMS-DFXn DMSO 2.5 mol% 120 1 98 71
2 Cu-MOFs-1 (Cu-TMU-17-NH2) PEG 0.05 g 110 5 94 72
3 Cu-MOFs-2 (Cu-TMU-17-NH2) PEG 0.05 g 110 5 95 72
4 CuO/aluminosilicate DMF 35 mg 110 2–13 80–93 73
5 Cu-TBA@biochar PEG 0.78 mol% 130 7 98 74
6 SBA-15@glycine-Ni PEG 0.04 g 100 110 98 78
7 SBA-15@glycine-Cu PEG 0.04 g 100 110 98 78
8 SBA-15/thioamide-Cu(i) H2O 1 mol% 80 240 97 79
9 Cu(ii)-DCC-CMK-3 PEG 20 mg 120 90 97 80
10 Cu(ii) immobilized on Fe3O4@SiO2@l-arginine PEG 1.0 mol% 120 3 95 81
11 Fe3O4@SiO2-DAQ-Cu(ii) DMF 0.9 mol% 110 2.5 95 82
12 Fe3O4@SiO2/ligand/Cu(ii) DMF 0.4 mol% 110 4 92 83
13 Fe3O4@SiO2/salen Cu(ii) DMF 0.4 mol% 120 6 92 84
14 Fe3O4-AMPD-Cu 85
15 Cu(ii) immobilized on aminated epichlorohydrin activated silica (CAES) DMSO 1.0 mol% 130 1 95 86
16 Cu(ii) immobilized on Fe3O4@SiO2@l-histidine PEG 0.05 g 120 60 95 87