Copper-based nano-catalyst catalyzed protocol for the synthesis of 1-substituted tetrazole containing scaffolds via one-pot MCR of triethyl orthoformate, amines and azide.
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| Entry | Catalyst | Solvent | Catalyst loading | Temperature (°C) | Time (h) | Yield (%) | Ref. |
| 1 | Fe3O4/SiO2/CPTMS/MT/Cu | — | 50 mg | 40 | 2 | 94 | 88 |
| 2 | Fe3O4@SiO2/salen Cu(ii) | — | 0.4 mol% | 100 | 75 | 92 | 84 |
| 3 | Fe3O4@SiO2/ligand/Cu(ii) | — | 0.4 mol% | 100 | 0.75 | 93 | 83 |
| 4 | Fe3O4@SiO2-DAQ-Cu(ii) | — | 0.8 mol% | 100 | 1 | 96 | 82 |
| 5 | Fe3O4/SiO2/CPTMS/MT/Cu | H2O | 20 mg | 40 | 2 | 94 | 89 |
| 6 | Fe3O4/SiO2/CPTMS/AT/Cu | Ethanol | 20 mg | 100 | 1 | 97 | 90 |