Figure 5.

DE-miRNAs associated with the viral persistence of SARS-CoV-2 infection, see also Figure S8

(A), The volcano plot of LTNP vs STNP. Red dots represent the upregulated DE-miRNAs (fold change>1.5, p ≤ 0.05); blue dots represent the downregulated DE-miRNAs (fold change<0.67, p ≤ 0.05); gray dots represent miRNAs without significant changes (0.67 ≤ fold change≤1.5, p > 0.05).

(B), The heatmap of 20 DE-miRNAs in LTNP vs STNP. In the left panel, blue, orange, and purple squares represent the function of miRNAs associated with immune responses, virus infections, and lung diseases, respectively.

(C), The GO analysis of the targeted genes in LTNP vs STNP. Top 20 GO terms associated with immune responses, virus infections, and lung diseases were shown.

(D), The KEGG analysis of the targeted genes in LTNP vs STNP. Top 20 KEGG pathways associated with immune responses, virus infections, and lung diseases were shown.

(E), The important DE-miRNAs prioritized by XGBoost analysis.

(F), Receiver operating characteristic (ROC) and performance of the XGBoost model in the training set.

(G), ROC and performance of the XGBoost model in the test set.

(H), Normalized copy numbers of five representative DE-miRNAs in the LTNP vs STNP group, the bars showing the mean ± SD (LTNP n = 30, STNP n = 33).