REAGENT or RESOURCE	SOURCE	IDENTIFIER
Biological samples
Human blood samples (COVID-19)	The Renmin Hospital of Wuhan University-China	Data S1
Human blood samples (Healthy donors)	The First Affiliated Hospital of Xi’an Jiaotong University-China	Data S1
Chemicals, peptides, and recombinant proteins
PBS	ThermoFisher	Cat# 20,012,068
Ethanol	Sigma	Cat# E7023
SUPERase•In™ RNase Inhibitor	ThermoFisher	Cat# AM2694
Critical commercial assays
Plasma/Serum Circulating and Exosomal RNA Purification Kit	Norgen	Cat#51000
Next Multiplex Small RNA Library Prep Set	New England Biolabs	Cat#E7300
Qubit dsDNA HS Assay Kit	Invitrogen	Cat#Q32854
Deposited data
The raw sequence data http://www.ncbi.nim.nih.gov/geo/query/acc.cgi?acc=GSE166160	This paper	GEO: GSE166160
Software and algorithms
R	https://www.cran.r-project.org	V4.0.2
Prism (software)	https://www.graphpad.com	v8.0.2
Human Genomes	ftp://ftp.ensembl.org/pub/release-96/fasta/homo_sapiens/dna/
Hairpin RNA Structures Sequences Predication	http://rna.tbi.univie.ac.at/cgi-bin/RNAfold.cgi
ComputationalTarget Prediction Algorithms TargetScan	http://www.targetscan.org/vert_71/docs/help.html
ComputationalTarget Prediction Algorithms miRanda	http://cbio.mskcc.org/miRNA2003/miranda.html
Bowtie	http://bowtie-bio.sourceforge.net/bowtie2/index.shtml	V1.0.0
OmicStudio	http://www.omicstudio.cn/tool
Xgboost	Chen et al., 2019https://dl.acm.org/doi/10.1145/2939672.2939785#pill-authors__content	V1.4.1.1