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. 2022 Apr 26;22:160. doi: 10.1186/s12890-022-01935-x

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — A There was no statistically significant alterations in the mean linear intercepts obtained from mice (n = 6 animals per group) regardless of exposure. B Increased activation of caspase-3 was detected in WT (p = 0.03), RAGE TG (p = 0.02), and RAGE KO (p = 0.04) mice exposed to SHS compared to RA controls. Cleaved caspase-3 was significantly decreased in SHS-exposed RAGE KO mice (^) compared to SHS-exposed WT (p = 0.04) or RAGE TG (p = 0.03) mice (^p ≤ 0.05). Blots were cropped and densitometrically normalized to β-actin and ratios of cleaved caspase-3/β-actin are presented