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. 2022 Apr 27;21:105. doi: 10.1186/s12943-022-01578-w

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visithttp://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — TLNC1 is upregulated in liver cancer tissues. a Clustering and volcano plot of differential lncRNA profiles between liver cancer tissues and adjacent normal tissues of west china hospital (WCH) cohort (n = 11). b Clustering and volcano plot of differential lncRNA profiles between liver cancer tissues and adjacent normal tissues of TCGA LIHC cohort (n = 50). c Venn plot shows the overlapping between differentially expressed lncRNAs of WCH and TCGA cohorts. The box indicates the differentially expressed lncRNAs that are correlated with OS and DFS of liver cancer patients according to the TCGA LIHC dataset. d Results from qRT-PCR validating the expression levels of 5 lncRNAs in 20 paired liver cancer and normal tissues. e Quantification of TLNC1 expression in 72 paired liver cancer and normal tissues of WCH cohort. f Quantification of TLNC1 expression in liver cancer tissues (n = 371) and normal tissues (n = 50) of TCGA LIHC cohort. g Quantification of TLNC1 expression in 50 paired liver cancer and normal tissues of TCGA LIHC cohort