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. 2022 Apr 27;12:6890. doi: 10.1038/s41598-022-10168-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Heart function is similar in control and 2-DG treated mice. (a) Heart capacity was measured by MRI. Right and left ventricle End-Systolic and End-Diastolic Volume index, Stroke Volume index and Cardiac Output index, adjusted for body surface area (BSA = 20 × body weight (g) ^ 0.42). There was no significant difference in the Ejection Fraction (EF) (amount, or percentage, of blood that is ejected from the ventricles with each contraction (EF = (SV/EDV) × 100)), or the volume remaining after contraction (End-Systolic Volume (ESV) or systole). There was a small increase in the cardiac output index in the 2DG treated animals (n = 8) versus controls (n = 6) which was significant, p = 0.03 for the right ventricle and p = 0.02 for the left. (b) Selected parameters measured to assess cardiac function. Heart rate (beats per minute), End-Systolic volume (ESV), End-Diastolic volume (EDV): volume of blood in a ventricle at the end of diastole, just before systole starts, Stroke volume (SV): volume of blood pumped from the left ventricle per beat (SV = EDV-ESV), Ejection Fraction (EF) (amount, or percentage, of blood that is ejected from the ventricles with each contraction (EF = (SV/EDV) × 100)), and Cardiac Output index (COi). The last was derived from Cardiac Output (CO): amount of blood pumped by the heart per minute (CO = (Heart rate x SV)/1000) and the Cardiac Index (CI), which relates the cardiac output (CO) from left ventricle in one minute to body surface area (CI = (CO/BSA) × 10,000)). There were no significant differences in the EF, ESV, CO or CI.