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. 2022 Apr 27;12:6890. doi: 10.1038/s41598-022-10168-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The effect of 2DG on the balance between glycolytic and mitochondrial energy production contrasts with that of SARS-CoV2. The proteomic signature found in this study suggests that the principle effect of 2-deoxyglucose (2DG) in the heart is to shift the equilibrium from glycolytic to mitochondrial (OXPHOS/OP) ATP production, as occurs in cultured cells. These effects are opposite to those of SARS-CoV2 infection in cells (illustrated to the right), and so support the idea that 2-deoxyglucose could have anti-viral properties in vivo as well as in cultured cells³.