Effect of compound 17b on levels of BAX, Bcl-2, active caspases-9, and active caspases-3 protein expression in HepG-2 cells treated for 24 h.
| Sample | Protein expression (normalized to β-actin)a | ||||
|---|---|---|---|---|---|
| BAX | Bcl-2 | BAX/Bcl-2 ratio | Caspases-9 | Caspases-3 | |
| HepG-2 | 1.00 ± 0.31 | 1.00 ± 0.12 | 1.00 ± 0.38 | 1.00 ± 0.10 | 1.00 ± 0.13 |
| 17b/HepG-2 | 4.21 ± 0.60** | 0.32 ± 0.04* | 9.30 ± 2.66* | 1.74 ± 0.20* | 1.85 ± 0.26* |
a
Values are given as mean ± SEM of three independent experiments. *p < 0.05 and **p < 0.01 indicate statistically significant differences from the corresponding control (HepG-2) group in unpaired t-tests.