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. 2022 Apr 27;12:50. doi: 10.1186/s13578-022-00778-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Loss of Pten alters DNA damage signalling pathways in murine NSCLC. A Correlation of gene expression changes of KRas^G12D:Trp53 (KP6) relative to KRas^G12D:Trp53:Pten (KPP4). The diagonal line reflects a regression build on a linear model. R: Pearsons correlation coefficient. R = 0.9122. B Venn diagram of differentially up-regulated genes (log₂FC > 1.0 and q-value < 0.05) between KRas^G12D:Trp53 (KP6) relative to KRas^G12D:Trp53:Pten (KPP4). C Volcano blot of differentially up- and downregulated genes in KRas^G12D:Trp53:Pten (KPP4) relative to KRas^G12D:Trp53 (KP6).log₂FCcut-off > 1.0, −log10FC > 1.5. Highlighted are genes involved in IR resistance; SftpC, Slc34a2, Tub, Myh6 and Shh, or IR sensitivity, Wisp2 and Bex1. n = 3. D Gene set enrichment analysis (GSEA) of Gamma radiation response, doxorubicin resistance up, KRas targets up, AKT1 signaling via mTOR, mesenchymal transition and metastasis KRas^G12D:Trp53 (KP) relative to KRas^G12D:Trp53:Pten (KPP). n = 3 each. Table with normalized enrichment score ((N)ES) and p-value of GSEA. Also see Additional file 1: Fig. S3