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. 2022 Apr 11;13:862084. doi: 10.3389/fimmu.2022.862084

Table 1.

The 10 most cited papers on anti-PD1/PDL1 immunotherapy for cancers. a

Rank Title Corresponding author Year Total citations Average citations per year (rank)
1 Safety, Activity, and Immune Correlates of Anti-PD-1 Antibody in Cancer Topalian, SL 2012 7,983 833.0 (3)
2 Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer Borghaei, H 2015 5,521 883.4 (2)
3 Safety and Activity of Anti-PD-L1 Antibody in Patients with Advanced Cancer Brahmer, JR 2012 5,052 527.2 (11)
4 PD-1 Blockade in Tumors with Mismatch-Repair Deficiency Diaz, LA 2015 4,938 750.1 (4)
5 Pembrolizumab versus Chemotherapy for PD-L1-Positive Non-Small-Cell Lung Cancer Brahmer, JR 2016 4,866 941.8 (1)
6 Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma Hodi, FS 2015 4,791 737.1 (5)
7 Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer Brahmer, J 2015 4,405 677.7 (6)
8 Pembrolizumab for the Treatment of Non-Small-Cell Lung Cancer Garon, EB 2015 3,618 542.7 (10)
9 Nivolumab versus Everolimus in Advanced Renal-Cell Cancer Motzer, RJ 2015 3,453 559.9 (9)
10 Nivolumab in Previously Untreated Melanoma without BRAF Mutation Robert, C 2015 3,444 492.0 (14)
a

These 10 papers were published in the New England Journal of Medicine.

PD1, programmed cell death 1; PDL1, programmed cell death 1 ligand 1.