Skip to main content
. Author manuscript; available in PMC: 2022 Apr 27.
Published in final edited form as: Nat Struct Mol Biol. 2022 Jan 10;29(1):47–58. doi: 10.1038/s41594-021-00706-2

Extended Data Fig. 9 |. IMPDH1 Retinal Variant C-term disrupts interactions.

Extended Data Fig. 9 |

a, Evolutionary conservation of the C-terminus in canonical IMPDH1 and both retinal splice variants. b, Surface representation of octamer side view. Dotted box indicates the region shown in c-d. c-d, Each chain is a different color green, C-term residues 510–512 in orange, and IMP in purple. c, inhibited canonical IMPDH1. d, Inhibited retinal variant IMPDH1(546).