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. Author manuscript; available in PMC: 2022 Apr 27.
Published in final edited form as: Nat Struct Mol Biol. 2022 Jan 10;29(1):47–58. doi: 10.1038/s41594-021-00706-2

Extended Data Fig. 10 |. IMPDH1 disease mutants have a variety of assembly phenotypes.

Extended Data Fig. 10 |

negative stain EM of purified human IMPDH1. Scale bar 100 nm. reactions performed with 1 μM protein, 1 mM ATP, 5 mM GTP, 3 mM IMP, 5 mM nAD+.