TABLE 4.
Correlation between antibody response and adverse events of COVID-19 vaccines
| Type of reaction | Rho (P value)a of MN titer for: |
|||
|---|---|---|---|---|
| CoronaVac (n = 53) |
BNT162b2 (n = 80) |
|||
| Day 28 | Day 56 | Day 21 | Day 56 | |
| Systemic reactions | −0.16 (0.257)b | 0.10 (0.467) | 0.20 (0.083) | 0.008 (0.947) |
| Fever | 0.16 (0.147) | 0.22 (0.048) | ||
| Chills | −0.062 (0.668) | 0.047 (0.737) | 0.095 (0.404) | |
| Headache | 0.060 (0.678) | 0.038 (0.787) | 0.000 (0.998) | −0.086 (0.451) |
| Tiredness | −0.076 (0.600) | 0.051 (0.719) | 0.14 (0.211) | −0.025 (0.826) |
| Nausea | −0.089 (0.540) | 0.15 (0.271) | −0.058 (0.607) | −0.077 (0.499) |
| Vomiting | 0.21 (0.134) | 0.033 (0.771) | ||
| Diarrhea | 0.18 (0.217) | 0.28 (0.039) | 0.12 (0.308) | 0.13 (0.256) |
| Muscle pain | −0.059 (0.686) | 0.041 (0.772) | 0.17 (0.123) | −0.12 (0.282) |
| Joint pain | −0.089 (0.540) | −0.12 (0.396) | 0.12 (0.291) | −0.18 (0.112) |
| Skin rash | −0.062 (0.668) | −0.062 (0.661) | 0.19 (0.101) | 0.11 (0.324) |
| Local reactions | 0.14 (0.328) | 0.12 (0.400) | 0.11 (0.340) | −0.066 (0.565) |
| Pain | 0.14 (0.338) | 0.11 (0.417) | 0.051 (0.651) | −0.094 (0.411) |
| Redness | −0.062 (0.661) | 0.21 (0.062) | 0.036 (0.751) | |
| Swelling | 0.31 (0.028) | 0.10 (0.458) | 0.13 (0.270) | 0.077 (0.498) |
| Ecchymosis | 0.17 (0.131) | 0.12 (0.278) | ||
| Itching | 0.31 (0.028) | 0.15 (0.287) | 0.19 (0.099) | −0.044 (0.703) |
a
Rho, Spearman’ s correlation coefficient. A value of 0.5 > rho > 0.3 indicates low positive correlation. A P value of <0.05 indicates that the correlation coefficient is statistically significant.
b
-rho, rho < 0 and indicates negative correlation.