TABLE 5.
Correlation between antibody response and adverse events of COVID-19 vaccines in females and males
| Type of reaction | Rho (P value)a of MN titer for: |
|||||||
|---|---|---|---|---|---|---|---|---|
| CoronaVac (n = 53) |
BNT162b2 (n = 80) |
|||||||
| Day 28 |
Day 56 |
Day 21 |
Day 56 |
|||||
| Female (n = 34) | Male (n = 19) | Female (n = 34) | Male (n = 19) | Female (n = 46) | Male (n = 34) | Female (n = 46) | Male (n = 34) | |
| Systemic reactions | −0.19 (0.281)b | −0.15 (0.546) | 0.12 (0.510) | −0.035 (0.886) | 0.25 (0.100) | 0.084 (0.638) | 0.031 (0.839) | −0.12 (0.517) |
| Fever | 0.20 (0.188) | 0.12 (0.414) | 0.35 (0.044) | |||||
| Chills | −0.089 (0.633) | 0.016 (0.930) | 0.063 (0.678) | 0.13 (0.475) | ||||
| Headache | 0.039 (0.834) | −0.023 (0.895) | 0.046 (0.764) | −0.159 (0.370) | −0.10 (0.501) | −0.12 (0.514) | ||
| Tiredness | −0.12 (0.520) | −0.081 (0.743) | −0.085 (0.634) | 0.22 (0.356) | 0.11 (0.451) | 0.163 (0.357) | 0.035 (0.816) | −0.11 (0.530) |
| Nausea | −0.13 (0.492) | 0.16 (0.359) | −0.032 (0.832) | −0.133 (0.455) | −0.048 (0.754) | −0.16 (0.389) | ||
| Vomiting | 0.26 (0.134) | 0.029 (0.849) | ||||||
| Diarrhea | 0.19 (0.300) | 0.21 (0.226) | 0.40 (0.087) | 0.13 (0.381) | 0.19 (0.201) | −0.087 (0.631) | ||
| Muscle pain | −0.052 (0.779) | −0.12 (0.633) | 0.21 (0.227) | −0.42 (0.071) | 0.26 (0.077) | −0.062 (0.727) | −0.11 (0.462) | −0.17 (0.334) |
| Joint pain | −0.089 (0.633) | −0.081 (0.743) | −0.067 (0.707) | −0.29 (0.226) | 0.170 (0.261) | −0.022 (0.902) | −0.20 (0.182) | −0.21 (0.248) |
| Skin rash | −0.089 (0.633) | −0.11 (0.527) | 0.21 (0.154) | 0.13 (0.387) | 0.077 (0.670) | |||
| Local reactions | 0.12 (0.498) | 0.16 (0.521) | 0.01 (0.948) | 0.27 (0.258) | 0.038 (0.800) | 0.187 (0.289) | −0.10 (0.501) | −0.050 (0.781) |
| Pain | 0.11 (0.566) | 0.16 (0.521) | −0.007 (0.967) | 0.27 (0.258) | −0.043 (0.775) | 0.188 (0.288) | −0.12 (0.433) | −0.098 (0.586) |
| Redness | −0.11 (0.527) | 0.34 (0.023) | −0.054 (0.762) | 0.050 (0.739) | 0.016 (0.929) | |||
| Swelling | 0.36 (0.049) | 0.11 (0.527) | 0.081 (0.591) | 0.15 (0.414) | 0.014 (0.925) | 0.16 (0.389) | ||
| Ecchymosis | 0.19 (0.198) | 0.20 (0.175) | −0.087 (0.631) | |||||
| Itching | 0.36 (0.049) | 0.16 (0.362) | 0.32 (0.029) | 0.051 (0.775) | −0.023 (0.881) | −0.077 (0.669) | ||
a
Rho, Spearman’ s correlation coefficient. A value of 0.5 > rho > 0.3 indicates low positive correlation. A P value of <0.05 indicates that the correlation coefficient is statistically significant.
b
-rho, rho < 0 and indicates negative correlation.