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. 2022 Apr 7;96(8):e02013-21. doi: 10.1128/jvi.02013-21

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FIG 1 — Enzymatic inhibition of SARS-CoV-2 M^pro. (A) Inhibition of ebselen against SARS-CoV-2 M^pro. (B) Inhibition of PF-07321332 against SARS-CoV-2 M^pro. SARS-CoV-2 M^pro was preincubated in the reaction buffer with various concentrations of PF-07321332 at room temperature for 30 min before reacting with the FRET substrate. Ebselen was used as a control. The IC₅₀ was calculated using GraphPad Prism software.