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Comparison of the binding modes of different inhibitors targeting SARS-CoV-2 Mpro. (A to I) The binding pockets of PF-07321332 (A) (PDB ID 7VLQ), N3 (B) (PDB ID 6LU7), GC376 (C) (PDB ID 7D1M), boceprevir (D) (PDB ID 7BRP), 13b (E) (PDB ID 6Y2F), 11a (F) (PDB ID 6LZE), MPI3 (G) (PDB ID 7JQO), 5h (H) (PDB ID 7JKV), and carmofur (I) (PDB ID 7BUY) bound to SARS-CoV-2 Mpro are shown. Mpros are shown as the gray surface, and the inhibitors are shown as sticks.
