FIG 4.

NgR1 is dispensable for reovirus neural transmission following intramuscular inoculation. WT, JAM-A^−/−, NgR1^−/−, and DKO mice were inoculated intramuscularly in the hind limb with 5 × 10⁶ PFU of reovirus T3SA−. Titers in the (A) inoculated hind limb, (B) blood, (C) ISC, (D) SSC, and (E) brain at the indicated intervals are shown. Dotted lines indicate the limit of detection. n = 8 to 13 animals per group for each time point. Error bars indicate SEM. Titers in tissues from knockout animals were compared with those in WT mice at each time point. *, P < 0.05; **, P < 0.01; ***; P < 0.001 (two-way ANOVA with Dunnett’s multiple-comparison test).