FIG 5.

NgR1 is not required for serotype 1 reovirus replication in the murine brain. Newborn WT and NgR1^−/− mice were inoculated intracranially with 100 PFU of reovirus T1L. At 3, 6, and 9 days after inoculation, mice were euthanized, brains were removed and hemisected, and viral titers in homogenates of the inoculated half of the brain were determined by plaque assay. Results are expressed as mean viral titers. Error bars indicate SEM. n = 7 to 8 mice per group for each time point. Differences in titer between WT and NgR1^−/− mice at each time point were not significant (P > 0.05), as determined by two-way ANOVA with Dunnett’s multiple-comparison test.