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. 2022 Apr 27;130(4):046001. doi: 10.1289/EHP10092

Figure 3.

Figure 3 is a set of two strip plots. The first strip plot, plotting reference, species, strain (sex), exposure route, exposure, duration, and sample collection, including (bottom to top) Marques and others (reference 130), Mice, C D -1 (M), Prenatal, P F O S plus H F D, G D 1 -P N D 21, and P N D 90; Marques and others (reference 130), Mice, C D -1 (M), Prenatal, P F O S, G D 1 -P N D 21, and P N D 90; Marques and others (reference 130), Mice, C D -1 (F), Prenatal, P F O S plus H F D, G D 1 -P N D 21, and P N D 90; Marques and others (reference 130), Mice, C D -1 (F), Prenatal, P F O S, G D 1 -P N D 21, and P N D 90; Marques and others (reference 130), Mice, C D -1 (M F), Prenatal, P F O S plus H F D, G D 1 -P N D 21, and P N D 90; Marques and others (reference 130), Mice, C D -1 (M F), Prenatal, P F O S, G D 1 -P N D 21, and P N D 90; Lai and others (reference 128), Mice, C 57 B L 7 (M F), Prenatal, P F O S plus D E N, E 0 to E 18.5, and E O T; Marques and others (reference 130), Mice, C D -1 (dams), Gavage, P F O S plus H F D, G D 1 -P N D 21, and E O T; Marques and others (reference 130), Mice, C D -1 (dams), Gavage, P F O S, G D 1 -P N D 21, and E O T; Hamilton and others (reference 125), Mice, Cyp2b -null (F), Gavage, P F O S plus H F D, 3 W, and E O T; Hamilton and others (reference 125), Mice, h C Y P 2 B 6 -T g (F), Gavage, P F O S plus H F D, 3 W, and E O T; Hamilton and others (reference 125), Mice, h C Y P 2 B 6 -T g (M), Gavage, P F O S plus H F D, 3 W, and E O T; Hamilton and others (reference 125), Mice, Cyp2b -null (F), Gavage, P F O S, 3 W, and E O T; Hamilton and others (reference 125), Mice, h C Y P 2 B 6 -T g (F), Gavage, P F O S, 3 W, and E O T; Hamilton and others (reference 125), Mice, Cyp2b -null (M), Gavage, P F O S, 3 W, and E O T; Hamilton and others (reference 125), Mice, h C Y P 2 B 6 -T g (M), Gavage, P F O S, 3 W, and E O T; Huang and others (reference 126), Mice, Kunming (M), Gavage, P F O S plus G S P E, 21 D, and E O T; Huang and others (reference 126), Mice, Kunming (M), Gavage, P F O S, 21 D, and E O T; Xing and others (reference 138), Mice, C 57 B L 7 (M), Gavage, P F O S, 30 D, and E O T; Wang and others (reference 137), Mice, C 57 B L 7 (M), Gavage, P F O S, 16 D, and E O T; Qin and others (reference 133), Mice, C 57 B L 7 (M), Gavage, P F O S plus H F D, 4 W, and E O T; Qin and others (reference 133), Mice, C 57 B L 7 (M), Gavage, P F O S, 4 W, and E O T; Deng and others (reference 124), Mice, C 57 B L 6 (M), Gavage, P F O S plus P C B 126, 1 D, and 2 D Post; Deng and others (reference 124), Mice, C 57 B L 6 (M), Gavage, P F O S, 1 D, and 2 D Post; Su and others (reference 135), Mice, I C R (M), Gavage, P F O S plus V C 200, 21 D, and E O T; Su and others (reference 135), Mice, I C R (M), Gavage, P F O S plus V C 100, 21 D, and E O T; Su and others (reference 135), Mice, I C R (M), Gavage, P F O S, 21 D, and E O T; Lv and others (reference 129), Mice, negative (M), Gavage, P F O S plus Nar, 21 D, and E O T; Lv and others (reference 129), Mice, negative (M), Gavage, P F O S, 21 D, and E O T; Yan and others (reference 89), Mice, B A L B c (M), Gavage, P F O S, 28 D, and EOT; Martin and others (reference 99), Rats, S D (M), Gavage, P F O S, and 5 D; Martin and others (reference 99), Rats, S D (M), Gavage, P F O S, and 2 D; Martin and others (reference 99), Rats, S D (M), Gavage, P F O S, and 1 D; Wan and others (reference 121), Rats, S D (M), Gavage, P F O S, 28 D, and EOT; Kim and others (reference 118), Rats, S D (F), Gavage, P F O S, 28 D, and EOT; Kim and others (reference 118), Rats, S D (M), Gavage, P F O S, 28 D, and EOT; Han and others (reference 117), Rats, S D (M), Gavage, P F O S, 28 D, and EOT; Han and others (reference 116), Rats, S D (M), Gavage, P F O S, 28 D, and EOT; Curran and others (reference 113), Rats, S D (F), Diet, P F O S, 28 D, and EOT; and Curran and others (reference 113), Rats, S D (M), Diet, P F O S, 28 D, and EOT (y-axis) across Dose (milligrams per kilogram), ranging from 0 to 100 in increments of 50 and 250 (x-axis). The second strip plot, plotting reference, species, strain (sex), exposure route, exposure, duration, and sample collection, including (bottom to top) Zhang and others (reference 140), Mice, C 57 B L 6 (M), Diet, P F O S plus C S, 6 W, and E O T; Zhang and others (reference 140), Mice, C 57 B L 6 (M), Diet, P F O S, 6 W, and E O T; Zhang and others (reference 140), Mice, C 57 B L 6 (M), Diet, P F O S plus m M C D, 2 W, and E O T; Zhang and others (reference 140), Mice, C 57 B L 6 (M), Diet, P F O S, 2 W, and E O T; Qazi and others (reference 132), Mice, C 57 B L 6 (M), Diet, P F O S plus Con A, 28 D, and E O T; Qazi and others (reference 132), Mice, C 57 B L 6 (M), Diet, P F O S, 28 D, and E O T; Qazi and others (reference 132), Mice, C 57 B L 6 (M), Diet, P F O S plus Con A, 10 D, and E O T; Qazi and others (reference 132), Mice, C 57 B L 6 (M), Diet, P F O S, 10 D, and E O T; Qazi and others (reference 104), Mice, C 57 B L 6 (M), Diet, P F O S, 10 D, and E O T; Butenhoff and others (reference 122), Rats, S D (F), Inhalation, P F O S, 13 W asterisk, and 4 W Post; Butenhoff and others (reference 122), Rats, S D (F), Inhalation, P F O S, 13 W asterisk, and E O T; Butenhoff and others (reference 122), Rats, S D (M), Inhalation, P F O S, 13 W asterisk, and 4 W Post; Butenhoff and others (reference 122), Rats, S D (M), Inhalation, P F O S, 13 W asterisk, and EOT; Bagley and others (reference 29), Rats, S D (F), Diet, P F O S plus C S, 23 D, and E O T; Bagley and others (reference 29), Rats, S D (F), Diet, P F O S, 23 D, and E O T; Bagley and others (reference 29), Rats, S D (F), Diet, P F O S plus C S, 16 D, and E O T; Bagley and others (reference 29), Rats, S D (F), Diet, P F O S, 16 D, and E O T; Bagley and others (reference 29), Rats, S D (F), Diet, P F O S plus C S, 9 D, and E O T; Bagley and others (reference 29), Rats, S D (F), Diet, P F O S, 9 D, and E O T; Bagley and others (reference 29), Rats, S D (F), Diet, P F O S plus C S, 2 D, and E O T; Bagley and others (reference 29), Rats, S D (F), Diet, P F O S, 2 D, and E O T; Bagley and others (reference 29), Rats, S D (M), Diet, P F O S plus C S, 23 D, and E O T; Bagley and others (reference 29), Rats, S D (M), Diet, P F O S, 23 D, and E O T; Bagley and others (reference 29), Rats, S D (M), Diet, P F O S plus C S, 16 D, and E O T; Bagley and others (reference 29), Rats, S D (M), Diet, P F O S, 16 D, and E O T; Bagley and others (reference 29), Rats, S D (M), Diet, P F O S plus C S, 9 D, and E O T; Bagley and others (reference 29), Rats, S D (M), Diet, P F O S, 9 D, and E O T; Bagley and others (reference 29), Rats, S D (M), Diet, P F O S plus C S, 2 D, and E O T; Bagley and others (reference 29), Rats, S D (M), Diet, P F O S, 2 D, and E O T; Butenhoff and others (reference 95), Rats, S D (M), Diet, P F O S, 52 W, and E O T; Butenhoff and others (reference 95), Rats, S D (M), Diet, P F O S, 52 W, and W 27; Butenhoff and others (reference 95), Rats, S D (M), Diet, P F O S, 52 W, and W 14; Butenhoff and others (reference 95), Rats, S D (M), Diet, P F O S, 52 W, and W 4; Butenhoff and others (reference 95), Rats, S D (F), Diet, P F O S, 52 W, and E O T; Butenhoff and others (reference 95), Rats, S D (F), Diet, P F O S, 52 W, and W 27; Butenhoff and others (reference 95), Rats, S D (F), Diet, P F O S, 52 W, and W 14; Butenhoff and others (reference 95), Rats, S D (F), Diet, P F O S, 52 W, and W 4; Elcombe and others (reference 114), Rats, S D (M), Diet, P F O S, 28 D, and E O T; Elcombe and others (reference 114), Rats, S D (M), Diet, P F O S, 7 D, and E O T; Elcombe and others (reference 114), Rats, S D (M), Diet, P F O S, 1 D, and E O T; Elcombe and others (reference 115), Rats, S D (M), Diet, P F O S, 7 D, and 84 D Post; Elcombe and others (reference 115), Rats, S D (M), Diet, P F O S, 7 D, and 56 D Post; Elcombe and others (reference 115), Rats, S D (M), Diet, P F O S, 7 D, 28 D, and EOT Post; Elcombe and others (reference 115), Rats, S D (M), Diet, P F O S, 7 D, and 1 D Post; Seacat and others (reference 120), Rats, S D (M), Diet, P F O S, 14 W, and E O T; and Seacat and others (reference 120), Rats, S D (F), Diet, P F O S, 14 W, and E O T (y-axis) across Dose (parts per million), ranging from 0 to 100 in increments of 50 and 300 (x-axis).

Strip plots for PFOS and ALT in rodent studies. Triangles indicate a significant increase in ALT relative to control. Diamonds indicate a significant decrease in ALT relative to control. Circles indicate no significant change in ALT relative to control. Plots are ordered by species and strain. In the study by Butenhoff et al.122, atmospheric exposure occurred for 5 h/d, 5 d/wk. An accessible version of this figure is available in Table S6. Note: ALT, alanine aminotransferase; CS, choline supplementation; Con A, concanavalin A; D, day; DEN, diethylnitrosamine; EOT, end of treatment; F, female; GD, gestational day; GSPE, grape seed proanthocyanidin extract; HFD, high-fat diet; M, male; mMCD, marginal methionine/choline-deficient diet; Nar, naringin; PCB, polychlorinated biphenyl; PFOS, perfluorooctanesulfonic acid; PND, postnatal day; SD, Sprague Dawley; VC, vitamin C; W, week.