. 2001 Apr;45(4):1244–1248. doi: 10.1128/AAC.45.4.1244-1248.2001

TABLE 3.

Selection of mutants resistant to Q-D and rifampin in cardiac vegetations from rabbits with aortic endocarditis due to S. aureus after a 4-day treatment with Q-D and/or rifampin

Regimen	No. of animals with Q-D or rifampin mutants/ no. of treated animals with strain^a:
	HM1054 (Q^s D^s)		RP13 (Q^s D^r)		HM1054R (Q^r D^s)
	Q-D mt	RIF mt	Q-D mt	RIF mt	Q-D mt	RIF mt
Q-D	0/9^b		1/12^b ^c		0/5
Rifampin		2/4^d		5/6^d		Not done
Q-D + rifampin	0/6	0/6	0/10	0/10	0/13	11/13^d

Mutants were selected on agar containing 2 times the MIC of Q-D and 10 times the MIC of rifampin. mt, mutants; RIF, rifampin.

Results were previously published (23).

MIC of Q-D, 8 μg/ml.

MICs of rifampin, >500 μg/ml.