Table 2.
Demographic and clinical characteristics of the study participants undergoing controlled ovarian hyper-stimulation during IVF
| Control (n = 15), median (IQR) | PCOS (n = 14), median (IQR) | P value | |
|---|---|---|---|
| Age, years | 28 (22–31) | 28.50 (25.75–31) | 0.430 |
| BMI (kg/m2) | 20.50 (18.40–25.40) | 24.50 (21.58–28.26) | 0.077 |
| Basal LH levels (µU/mL) | 3.6 (2.8–6.13) | 7.57 (4.9–8.995) | 0.0007** |
| Basal FSH levels (µU/mL) | 5 (4.48–7.09) | 5.65 (4.11–6.14) | 0.810 |
| LH:FSH | 0.656 (0.54–0.9) | 1.37 (1.04–1.65) | 0.0006** |
| Prolactin (ng/mL) | 14.2 (6.37–16.98) | 12.3 (10.18–14.56) | 0.743 |
| TSH (mIU/mL) | 1.87 (1.6–3.08) | 2.08 (1.29–3.20) | 0.777 |
| E2 (ng/mL) before hCG administration | 1.68 (1.5–2.24) | 1.79 (1.22–2.4) | 0.948 |
| E2 (ng/mL) on hCG administration day | 2.49 (2.1–3.8) | 2.54 (2.25–4.19) | 0.694 |
| aE2 (ng/mL) Serum | 2.14 (2–2.8) | 0.997 (0.078–2.61) | 0.067 |
| aE2 (ng/mL) FF | 840 (435–1042) | 912.6 (608.9–1260) | 0.420 |
| aP4 (ng/mL) Serum | 2.6 (1–5) | 0.73 (0.188–2.98) | 0.073 |
| aP4 (μg/mL) FF | 23.02 (15–30) | 15.48 (7.03–21.06) | 0.036* |
| aTT (ng/dL) Serum | 111 (90–128) | 161.5 (123.7–192.5) | 0.019* |
| aTT (ng/dL) FF | 372.6 (260–600) | 617.5 (400.3–787.4) | 0.025* |
| aSHBG (nmol/L) Serum | 125 (80–234) | 89.85 (47.25–108.4) | 0.045* |
| aSHBG (nmol/L) FF | 153.4 (133.2–175) | 95.55 (78.25–149.9) | 0.034* |
| aFree T (pmol/L) Serum | 28.10 (19.5–34) | 52.87 (36.37–61.75) | 0.001** |
| aFree T (pmol/L) FF | 87.09 (58–127) | 183 (142.8–224.5) | 0.0005** |
| aBio T (nmol/L) Serum | 0.66 (0.46–0.79) | 1.24 (0.85–1.45) | 0.001** |
| aBio T (nmol/L) FF | 2.09 (1.35–2.98) | 4.3 (3.34–4.93) | 0.0005** |
| aFAI Serum | 3.28 (2.26–4.25) | 6.24 (4.27–8.88) | 0.001** |
| aFAI FF | 7.66 (6.44–13.15) | 19.50 (16.29–24.41) | 0.0004** |
Data are represented as the median (inter-quartile range) for demographic, hormonal, and biochemical profiles compared between control and women with PCOS. Statistical comparison was performed using the Mann–Whitney U test. P values < 0.05 are considered significant for all statistical tests
IVF in vitro fertilization, BMI body mass index, LH luteinizing hormone, FSH follicle-stimulating hormone, TSH thyroid stimulating hormone, FF follicular fluid, E2 estradiol, P4 progesterone, TT total testosterone, SHBG sex hormone-binding globulin, Free T free testosterone, Bio T bioavailable testosterone, FAI free androgen index
*P < 0.05, **P < 0.01
aParameters were measured in serum and follicular fluids obtained on the day of ovum pick-up