Table 2.
Text mining and browsing databases to determine the physiological function of lncRNAs in pathogenesis based on the targets
| Disease name | Regulator | Target gene | Effect direction | Expression pattern | Regulatory mechanism | Function |
|---|---|---|---|---|---|---|
| Glioblastoma | TUG1 | VEGFα | Positive effect | Upregulation | ceRNA(miR-299) | Angiogenesis ( +) |
| Hepatoblastoma | TUG1 | VEGFα | Positive effect | Upregulation | ceRNA(miR-34a-5p) | Cell growth (-) angiogenesis (-) |
| Malignant glioma | TUG1 | PTEN | Positive effect | Upregulation | ceRNA(miR-26a) | Tumor-suppressive function ( +) |
| Breast cancer | HOTAIR | PTEN | Negative effect | Upregulation | Histone modification |
Cell proliferation ( +) Cell invasion ( +) Cell migration ( +) |
| Laryngeal squamous cell carcinoma | HOTAIR | PTEN | Negative effect | Upregulation | DNA methylation | Oncogenic role ( +) |
| Liver fibrosis | HOTAIR | PTEN | Positive effect | Upregulation |
DNA methylation ceRNA(miR-29b) |
Fibrotic ( +) |
| Cervical cancer | HOTAIR | VEGFα | Positive effect | Upregulation | Not reported |
Cell motility ( +) Cell metastasis ( +) |
| Gastric cancer | HOTAIR | VEGFα | Positive effect | Upregulation | Not reported |
Chemoresistance ( +) PI3K/AKT signaling pathway ( +) |
| Hepatocellular carcinoma | HOTAIR | VEGFα | Positive effect | Upregulation | Not reported | Cell proliferation ( +) |
| Nasopharynx carcinoma | HOTAIR | VEGFα | Positive effect | Upregulation | Not reported | Angiogenesis ( +) |
| Cardiac fibrosis | GAS5 | PTEN | Positive effect | Downregulation | ceRNA(miR-21) |
Cell proliferation (-) Cell growth (-) fibrotic (-) |
| Endometrial cancer | GAS5 | PTEN | Positive effect | Downregulation | ceRNA(miR-103a-3p) | Apoptosis process ( +) |
| Hepatocellular carcinoma | GAS5 | PTEN | Positive effect | Downregulation | ceRNA(miR-21) |
Cell migration (-) Cell invasion (-) |
| Her2-receptor positive breast cancer | GAS5 | PTEN | Positive effect | Downregulation | ceRNA(miR-21) |
Chemoresistance ( +) Cell proliferation ( +) |
| Non-small cell lung cancer | GAS5 | PTEN | Positive effect | Downregulation | ceRNA(miR-21) | Chemosensitivity ( +) |
| Pancreatic cancer | GAS5 | PTEN | Positive effect | Downregulation | ceRNA(miR-32-5p) | Cell metastasis (-) |
| Cervical cancer | GAS5 | PTEN | Positive effect | Downregulation | Not reported | Chemoresistance (-) |
| Colorectal cancer | GAS5 | VEGFα | Negative effect | Downregulation | Not reported |
NF-kB signaling pathway (-) ERK1/2 signaling pathway (-) Tumorigenesis (-) |
| Malignant glioma | MEG3 | PTEN | Positive effect | Downregulation | ceRNA(miR-19a-3p) |
Cell proliferation (-) Cell migration (-) Cell invasion (-) |
| Pulmonary hypertension | MEG3 | PTEN | Positive effect | Downregulation | ceRNA(miR-21) |
Cell proliferation ( +) Cell migration ( +) |
| Osteoarthritis | MEG3 | VEGFα | Negative effect | Downregulation | Not reported | Angiogenesis (-) |