TABLE 1.
Point mutations in the mutant spectra of SARS-CoV-2 isolatesa
| Characteristics | Result for patients with disease severity |
|||
|---|---|---|---|---|
| Total | Mild | Moderate | Exitus | |
| nsp12 | ||||
| Transitions (%) | 68 (97.14%) | 56 (96.55%) | 3 (100%) | 10 (100%) |
| Transversions (%) | 2 (2.86%) | 2 (3.45%) | 0 (0%) | 0 (0%) |
| P value | <0.001 | <0.001 | 0.051 | <0.001 |
| Significanceb | *** | *** | n.s. | *** |
| Synonymous (%) | 29 (41.43%) | 24 (41.38%) | 2 (66.67%) | 4 (40%) |
| Nonsynonymous (%) | 41 (58.57%) | 34 (58.62%) | 1 (33.33%) | 6 (60%) |
| P value | 0.031 | 0.047 | 0.5 | 0.327 |
| Significanceb | * | * | n.s. | n.s. |
| Spike | ||||
| Transitions (%) | 26 (96.30%) | 24 (100%) | 3 (100%) | 0 (0%) |
| Transversions (%) | 1 (3.70%) | 0 (0%) | 0 (0%) | 1 (100%) |
| P value | <0.001 | <0.001 | 0.051 | 0.5 |
| Significanceb | *** | *** | n.s. | n.s. |
| Synonymous (%) | 11 (40.74%) | 10 (41.67%) | 1 (33.33%) | 0 (0%) |
| Nonsynonymous (%) | 16 (59.26%) | 14 (58.33%) | 2 (66.67%) | 1 (100%) |
| P value | 0.138 | 0.193 | 0.5 | 0.051 |
| Significanceb | n.s. | n.s. | n.s. | n.s. |
a
Different number of point mutations distributed according to COVID-19 severity in the nsp12 (polymerase)- and spike-coding regions.
b
The statistical significance of the differences (n.s., not significant; *, P < 0.05; ***, P < 0.001) was calculated using the proportion test.