TABLE 1.
Antimicrobial drug susceptibility profilesa
| Antibiotics | MIC (mg/L)/antimicrobial susceptibility |
||||
|---|---|---|---|---|---|
| K. pneumoniae 1632 | K. pneumoniae 1864 | E. coli J53 | Transconjugants |
||
| p1632-2-J53 (armA) | p1864-1-J53 (armA and iuc operon) | ||||
| MEM | >16/R | >16/R | ≤0.06/S | ≤0.06/S | ≤0.06/S |
| IPM | 16/R | 16/R | ≤0.25/S | ≤0.25/S | ≤0.25/S |
| ETP | >2/R | >2/R | ≤0.015/S | ≤0.015/S | ≤0.015/S |
| GEN | >1024/R | >1024/R | ≤1/S | 1024/R | 1024/R |
| AMK | >1024/R | >1024/R | ≤16/S | 1024/R | 1024/R |
| AMP | >32/R | >32/R | ≤8/S | >32/R | >32/R |
| CZO | >32/R | >32/R | ≤2/S | >32/R | >32/R |
| CAZ | >128/R | >128/R | ≤0.25/S | 1/S | 1/S |
| FEP | >16/R | >16/R | ≤0.5/S | 4/SDD | 8/SDD |
| CSL | >64/32/R | >64/32/R | ≤16/8/S | ≤16/8/S | ≤16/8/S |
| SAM | >32/16/R | >32/16/R | ≤16/4/S | ≤16/4/S | 16/8/I |
| FOX | >32/R | >32/R | ≤8/S | ≤8/S | ≤8/S |
| CXM | >16/R | >16/R | 8/S | >16/R | >16/R |
| CTX | >64/R | >64/R | ≤0.12/S | 32/R | 32/R |
| TZP | >128/4/R | >128/4/R | ≤16/4/S | ≤16/4/S | ≤16/4/S |
| AMC | >32/16/R | >32/16/R | ≤8/4/S | ≤8/4/S | ≤8/4/S |
| LVX | >8/R | >8/R | ≤0.12/S | ≤0.12/S | ≤0.12/S |
| MFX | >2/R | >2/R | ≤0.25/S | ≤0.25/S | ≤0.25/S |
| TCY | ≤2/S | ≤2/S | ≤2/S | ≤2/S | ≤2/S |
| ATM | >16/R | >16/R | ≤4/S | ≤4/S | ≤4/S |
| NIT | >64/R | >64/R | ≤16/S | ≤16/S | ≤16/S |
| SXT | >4/76/R | ≤0.5/9.5/S | ≤0.5/9.5/S | >4/76/R | >4/76/R |
| Caz/AVI | 2/4/S | 2/4/S | ≤0.5/4/S | ≤0.5/4/S | ≤0.5/4/S |
| TGC | 0.5/S | 0.5/S | ≤0.25/S | ≤0.25/S | ≤0.25/S |
aMIC, minimal inhibitory concentration; MEM, meropenem; IPM, imipenem; ETP, ertapenem; Caz/AVI, ceftazidime-avibactam; TGC, tigecycline; FOS, fosfomycin; AMP, ampicillin; CZO, cefazolin; CAZ, ceftazidime; FEP, cefepime; CSL, cefoperazone/sulbactam; SAM, ampicillin/sulbactam; FOX, cefoxitin; CXM, cefuroxime; CTX, cefotaxime; TZP, piperacillin-tazobactam; AMC, amoxicillin/clavulanic acid; LVX, levofloxacin; MFX, moxifloxacin; TCY, tetracycline; GEN, gentamicin; AMK, amikacin; ATM, aztreonam; NIT, nitrofurantoin; SXT, trimethoprim/sulfamethoxazole.