TABLE 4.
Correlation and comparison of antimicrobial susceptibility profiles with Nocardia species or complexes designationa
| Similar studies | Involved Nocardia species/complexes | No. of Nocardia isolates | Susceptibility (%)b |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Linezolid | Amikacin | TMP-SMX | Ciprofloxacin | Moxifloxacin | Ceftriaxone | Imipenem | Amoxicillin-clavulanic acid | Doxycycline | Minocycline | Tobramycin | Clarithromycin | |||
| N. farcinica | ||||||||||||||
| Expected patternc | N. farcinica | S | S | S | S | NA | R | V | S | NA | V | R | R | |
| This study | N. farcinica | 176 | 100 | 100 | 97.7 | 68.8 | 90.3 | 8.5 | 39.8 | 61.9 | 18.8 | 26.1 | 14.2 | 4.0 |
| Study 1 (6) | N. farcinica, N. kroppenstedtii | 319 | 100 | 100 | 99 | 49 | 76 | 3 | 83 | 96 | 2 | 7 | 1 | 0 |
| Study 2 (11) | N. farcinica | 38 | 100 | 100 | 73.7 | 28.9 | 50 | 2.6 | 5.3 | 23.7 | 2.6 | 2.6 | 2.6 | 2.6 |
| Study 3 (12) | N. farcinica | 204 | 100 | 100 | 99.5 | 43 | 79 | 3 | 33 | 76 | ND | 5 | 0.5 | 0.5 |
| Study 4 (13) | N. farcinica | 36 | 100 | 100 | 94 | 50 | 81 | 6 | 53 | 78 | 17 | 36 | 0 | 0 |
| N. cyriacigeorgica | ||||||||||||||
| Expected patternc | N. cyriacigeorgica | S | S | S | R | NA | S | S | R | NA | V | S | R | |
| This study | N. cyriacigeorgica | 126 | 100 | 100 | 100 | 2.4 | 18.3 | 66.7 | 58.7 | 6.3 | 47.6 | 42.9 | 96 | 19.8 |
| Study 1 (6) | N. cyriacigeorgica | 352 | 100 | 99 | 100 | 0 | 1 | 64 | 99 | 8 | 11 | 14 | 99 | 1 |
| Study 2 (11) | N. cyriacigeorgica | 61 | 100 | 100 | 100 | 0 | 0 | 80.3 | 6.6 | 3.3 | 16.4 | 8.2 | 100 | 0 |
| Study 3 (12) | N. cyriacigeorgica | 264 | 100 | 100 | 100 | 0 | 4 | 88 | 43 | 3 | ND | 6 | 99.2 | 1 |
| Study 4 (13) | N. cyriacigeorgica | 20 | 100 | 100 | 100 | 0 | 0 | 95 | 90 | 15 | 50 | 85 | 100 | 25 |
| N. abscessus | ||||||||||||||
| Expected patternc | N. abscessus complex | S | S | S | R | NA | S | V | S | NA | V | V | R | |
| This study | N. abscessus, N. asiatica, N. beijingensis | 54 | 100 | 100 | 100 | 18.5 | 29.6 | 90.7 | 46.3 | 48.1 | 83.3 | 79.6 | 87 | 53.7 |
| Study 1 (6) | N. abscessus, N. arthritidis, N. asiatica, N. beijingensis, N. pneumoniae | 205 | 100 | 100 | 100 | 3 | 13 | 93 | 64 | 61 | 87 | 94 | 100 | 38 |
| Study 2 (11) | ND | 4 | 100 | 100 | 100 | 0 | 0 | 75 | 0 | 50 | 100 | 75 | 100 | 50 |
| Study 3 (12) | N. abscessus, N. arthritidis, N. asiatica | 110 | 100 | 100 | 100 | 0 | 8 | 98 | 31 | 78 | ND | 85 | 100 | 29 |
| Study 4 (13) | N. abscessus, N. abscessus/arthritidis-like species cluster | 9 | 100 | 100 | 100 | 11 | 11 | 100 | 22 | 100 | 89 | 89 | 100 | 11 |
| N. otitidiscaviarum | ||||||||||||||
| Expected patternc | N. otitidiscaviarum | S | S | S | S | NA | R | R | R | NA | V | V | V | |
| This study | N. otitidiscaviarum | 26 | 100 | 100 | 100 | 7.7 | 46.2 | 3.8 | 3.8 | 11.5 | 53.8 | 61.5 | 57.7 | 3.8 |
| Study 1 (6) | N. otitidiscaviarum | 30 | 100 | 100 | 87 | 0 | 23 | 0 | 3 | 0 | 43 | 60 | 53 | 17 |
| Study 2 (11) | N. otitidiscaviarum | 2 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
| Study 3 (12) | N. otitidiscaviarum | 29 | 100 | 100 | 100 | 7 | 35 | 0 | 7 | 0 | ND | 45 | 62 | 7 |
| Study 4 (13) | N. otitidiscaviarum | 6 | 100 | 100 | 83 | 0 | 17 | 0 | 0 | 0 | 17 | 33 | 50 | 0 |
| N. brasiliensis | ||||||||||||||
| Expected patternc | N. brasiliensis | S | S | S | R | V | R | S | S | S | R | |||
| This study | N. brasiliensis | 18 | 100 | 100 | 100 | 0 | 94.4 | 27.8 | 0 | 94.4 | 22.2 | 83.3 | 100 | 11.1 |
| Study 1 (6) | N. brasiliensis | 223 | 100 | 100 | 100 | 0 | 40 | 2 | 8 | 99 | 5 | 16 | 100 | 0 |
| Study 2 (11) | N. brasiliensis | 52 | 100 | 100 | 98.1 | 0 | 78.8 | 38.5 | 0 | 90.4 | 11.5 | 15.4 | 100 | 0 |
| Study 3 (12) | N. brasiliensis | 148 | 100 | 100 | 100 | 1 | 99 | 49 | 1 | 95.3 | ND | 24 | 100 | 3 |
| Study 4 (13) | N. brasiliensis | 6 | 100 | 100 | 100 | 0 | 67 | 33 | 17 | 100 | 17 | 67 | 100 | 0 |
| N. transvalensis | ||||||||||||||
| Expected patternc | N. transvalensis complex | S | R | S | S | NA | S | V | V | NA | V | R | R | |
| This study | N. blacklockiae, N. transvalensis, N. wallacei | 11 | 100 | 72.7 | 100 | 72.7 | 90.9 | 63.6 | 36.4 | 63.6 | 18.2 | 27.3 | 9.1 | 27.3 |
| Study 1 (6) | N. blacklockiae, N. transvalensis, N. wallacei | 121 | 100 | 26 | 88 | 49 | 72 | 64 | 9 | 89 | 10 | 31 | 0 | 2 |
| Study 2 (11) | ND | 4 | 100 | 50 | 75 | 100 | 100 | 100 | 25 | 75 | 25 | 25 | 0 | 50 |
| Study 3 (12) | N. transvalensis, N. wallacei | 83 | 100 | 28 | 81 | 84 | 100 | 63 | 6 | 47 | ND | 15 | 4 | 4 |
| Study 4 (13) | N. transvalensis, N. wallacei | 5 | 100 | 20 | 80 | 100 | 80 | 100 | 0 | 40 | 20 | 20 | 0 | 20 |
| N. nova | ||||||||||||||
| Expected patternc | N. nova complex | S | S | S | R | NA | S | S | R | NA | V | R | S | |
| This study | N. nova, N. africana, N. elegans, N. veterana | 11 | 100 | 100 | 100 | 0 | 27.3 | 72.7 | 90.9 | 18.2 | 27.3 | 36.4 | 45.5 | 72.7 |
| Study 1 (6) | N. nova, N. africana, N. elegans, N. veterana, N. aobensis, N. cerradoensis, N. kruczakiae, N. mikamii, N. vermiculata | 452 | 100 | 100 | 100 | 1 | 3 | 14 | 100 | 4 | 1 | 19 | 3 | 97 |
| Study 2 (11) | N. nova, N. veterana | 80 | 100 | 100 | 93.8 | 3.8 | 6.3 | 60 | 96.3 | 6.3 | 3.8 | 15 | 13.8 | 95 |
| Study 3 (12) | N. nova, N. africana, N. elegans, N. veterana, N. kruczakiae, N. ikamii | 320 | 100 | 100 | 100 | 1 | 2 | 47 | 99 | 9 | ND | 12 | 13 | 97 |
| Study 4 (13) | N. nova, N. nova/cerradoensis/kruczakiae/aobensis-like species cluster | 28 | 100 | 100 | 100 | 0 | 7 | 85 | 93 | 26 | 11 | 56 | 7 | 100 |
| All Nocardia species | ||||||||||||||
| This study | All Nocardia species | 441 | 100 | 99.3 | 99.1 | 33.6 | 57.1 | 40.6 | 43.3 | 39.5 | 38.8 | 43.5 | 56.5 | 18.6 |
| Study 1 (6) | All Nocardia species | 2091 | 100 | 94.1 | 98 | 15.8 | 30.3 | 36 | 73.2 | 44.3 | 18.7 | 29.7 | 51.8 | 34.8 |
| Study 2 (11) | All Nocardia species | 270 | 100 | 99.3 | 90.7 | 11.5 | 32.2 | 53 | 33.7 | 25.2 | 12.6 | 14.4 | 58.1 | 37.4 |
| Study 3 (12) | All Nocardia species | 1299 | 100 | 95 | 98 | 17 | 40 | 56 | 49 | 37 | ND | 22 | 55 | 33 |
| Study 4 (13) | All Nocardia species | 149 | 100 | 99 | 97 | 22 | 40 | 65 | 59 | 40 | 37 | 61 | 53 | 37 |
a
For study 1 (6), the MICs reported as intermediate (I) were combined with resistant (R) for this study. NA, the expected antimicrobial susceptibility patterns are not available; ND, not determined.
b
The numbers in this section represent percentages of susceptibility (%) of the corresponding Nocardia species or species complexes.
c
Expected antimicrobial susceptibility patterns of the most commonly isolated Nocardia species or species complexes provided by CLSI standard M62 (15); the expected pattern “R/S/V” represents resistant/susceptible/variable pattern of the Nocardia species or species complexes, respectively.