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In vitro activity of cefiderocol with or without β-lactamase inhibitorsa
| Strains | β-lactamase | Cefiderocol MIC (mg/liter) |
|||
|---|---|---|---|---|---|
| -b | AVI | DPA | AVI+DPA | ||
| AR8416 | NDM-5 | >256 | >256 | 1 | 1 |
| AR8538 | NDM-1 × 2, DHA-1, SHV-12 | 32 | 8 | 2 | 1 |
| AR8334 | NDM-5, SHV-208 | 8 | 2 | 1 | 0.5 |
| AR8335 | NDM-1, SHV-12, IMP-4 | 8 | 1 | 1 | 0.06 |
AVI, avibactam; DPA, dipicolinic acid; MIC, minimum inhibitory concentration.
-, No β-lactamase inhibitor was added.
