TABLE 3.
Combined effect of deficiency of CirA and NDM-5 on cefiderocol resistance
| Strain | Description | MIC (mg/L)a |
|---|---|---|
| D3 | Wild type | 0.5 |
| D3-cirA-mutant | D3 with cirA mutation | 1 |
| D3-cirA-mutant+pAR8416-NDM5 | D3-cirA-mutant transformed with pAR8416-NDM5 | >256 |
| D3+pCR2.1-NDM5 | D3 transformed with pCR2.1-NDM5 | 4 |
| D3-cirA-mutant+pCR2.1-NDM5 | D3-cirA-mutant transformed with pCR2.1-NDM5 | >256 |
| AR8416-1+pCR2.1-NDM5 | AR8416-1 transformed with pCR2.1-NDM5 | >256 |
| D3+pCR2.1 vector | D3 transformed with pCR2.1 vector | 0.5 |
| AR8416-1+pCR2.1 vector | AR8416-1 transformed with pCR2.1 vector | 0.25 |
| DH5α + pCR2.1 vector | DH5α transformed with pCR2.1 vector | 0.125 |
| DH5α + pCR2.1-NDM5 | DH5α transformed with pCR2.1-NDM5 | 2 |
a
MIC, minimum inhibitory concentration.