TABLE 4.
Combined effect of deficiency of CirA and other types of carbapenemases on cefiderocol resistance
| Strain | Description | MIC (mg/L)a |
|---|---|---|
| D3+pCR2.1_NDM1 | D3 transformed with pCR2.1_NDM1 | 4 |
| D3+pCR2.1_KPC2 | D3 transformed with pCR2.1_KPC2 | 2 |
| D3+pCR2.1_IMP4 | D3 transformed with pCR2.1_IMP4 | 0.5 |
| D3+pCR2.1_OXA48 | D3 transformed with pCR2.1_OXA48 | 0.5 |
| D3+pCR2.1_OXA232 | D3 transformed with pCR2.1_OXA232 | 0.5 |
| D3-cirA-mutant+pCR2.1_NDM1 | D3-cirA-mutant transformed with pCR2.1_NDM1 | >256 |
| D3-cirA-mutant+pCR2.1_KPC2 | D3-cirA-mutant transformed with pCR2.1_KPC2 | 4 |
| D3-cirA-mutant+pCR2.1_IMP4 | D3-cirA-mutant transformed with pCR2.1_IMP4 | 1 |
| D3-cirA-mutant+pCR2.1_OXA48 | D3-cirA-mutant transformed with pCR2.1_OXA48 | 1 |
| D3-cirA-mutant+pCR2.1_OXA232 | D3-cirA-mutant transformed with pCR2.1_OXA232 | 1 |
| AR8416-1+pCR2.1_NDM1 | AR8416-1 transformed with pCR2.1_NDM1 | >256 |
| AR8416-1+pCR2.1_KPC2 | AR8416-1 transformed with pCR2.1_KPC2 | 1 |
| AR8416-1+pCR2.1_IMP4 | AR8416-1 transformed with pCR2.1_IMP4 | 0.25 |
| AR8416-1+pCR2.1_OXA48 | AR8416-1 transformed with pCR2.1_OXA48 | 0.5 |
| AR8416-1+pCR2.1_OXA232 | AR8416-1 transformed with pCR2.1_OXA232 | 0.25 |
a
MIC, minimum inhibitory concentration.