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. 2022 Mar 21;10(2):e01052-21. doi: 10.1128/spectrum.01052-21

TABLE 2.

Variable region of heavy chain and light chain of CD2V mAbs

mAb Variable region of heavy chain Variable region of light chain
18A3 MVKPGASVKISCKASGYSFTSYYIHWVKQRPGQGLEWIGWIFPGSGNTKYNEKFKGKATLTADTSSSTAYMQLSSLTSEDSAVYFCAQTGRVFAYWGQGTTVTVSSK
CDR-H1:GYSFTSYY
CDR-H2:IFPGSGNT
CDR-H3:AQTGRVFAY
MTQSPSSLSASLGERVSLTCRASQEISGYLSWLQQKPDGTIKRLIYAASTLDSGVPKRFSGSRSGSDYSLTISSLESEDFADYYCLQYASYPWTFGGGTKLESNGE
CDR-L1:QEISGY
CDR-L2:AASTLDS CDR-L3:LQYASYPWT
22B3 MHVQLQESGGGLVKPGGSLKLSCAASGFTFSSYAMSWVRQTPEKRLEWVASISSGGSTYYPDSVKGRFTISRDNARNILYLQMSSLRSEDTAMYFCARRYRYDAWFAYWGQGTTVTVSSK
CDR-H1:GFTFSSYA
CDR-H2:ISSGGST CDR-H3:ARRYRYDAWFAY
MTQSPAILSASPGEKVTMTCRASSSVSYMHWYQQKPGSSPKPWIYATSNLASGVPARFSGSGSGTSYSLTISRVEAEDVATYYCQQWSSNPRGRSVEAPSWKSNG
CDR-L1:SSVSY
CDR-L2:ATSNLAS
CDR-L3:QQWSSNPRGRSV
43C2 MAAQQSGAELMKPGASVKISCKATGYTFSTYWIEWVKQRPGHGLEWIGEILPGGGSTNYNEKFKGKAMFTADTSSNTAYMQLSSLASEDSAVYYCARVRYGNYGGNYYAMDYWGQGTTVTVSS
CDR-H1:GYTFSTYW CDR-H2:ILPGGGST CDR-H3:ARVRYGNYGGNYYAMDY
MDIELTQSPASLAVSLGQRATISYRASKSVSTSGYSYMHWNQQKPGQPPRLLIYLVSNLESGVPARFSGSGSGTDFTLNIHPVEEEDAATYYCQHIRELTRSEG
CDR-L1:KSVSTSGYSY CDR-L2:LVSNLES
CDR-L3:QHIRELTRSE
7E12 MEVQLQQSGAELVRPGASVKLSCKTSGYIFTSYWIHWVKQRSGQGLEWIARIYPGTGSTYYNEKFKGKATLTADKSSSTAYMQLSSLKSEDSAVYFCARGKYGNLYYFDYWGQGTTVTVSSK
CDR-H1:GYIFTSYW
CDR-H2:IYPGTGST CDR-H3:ARGKYGNLYYFDY
MDIELTQSPASLAVSLGQRATISYRASKSVSTSGYSYMHWNQQKPGQPPRLLIYLVSNLESGVPARFSGSGSGTDFTLNIHPVEEEDAATYYCQHIRELTRSEGAPSWKSNG
CDR-L1:KSVSTSGYSY
CDR-L2:LVSNLES
CDR-L3:QHIRELTRSEGA
13G11 MIMVQSQESGPDLVKPSQSLSLTCTVTGYSITSGYSWHWIRQFPGNKLEWMGYIHYSGVTNYNPSLKSRISITRDTSKNQFFLQLNSVTTEDTATYYCARAPLYYGNYVWFSYWGQGTTVTVSSK
CDR-H1:GYSITSGYS
CDR-H2:IHYSGVT CDR-H3:APLYYGNYVWFSY
MTCDIELTQSPASLSASVGETVTITCRASGNIHNYLAWYQQKQGKSPQLLVYNAKTLADGVPSRFSGSGSGSQYSLKINSLQPEDFGSYYCQHFWSTPWTFGGGTKLENQTDK
CDR-L1:GNIHNY
CDR-L2:NAKTLAD
CDR-L3:QHFWSTPWT