FIG 2.

Archaeal metabolites that are directly or indirectly involved in the initiation and/or progression of carcinogenesis. The pertinent enzymes of the metabolites are also shown in the figure. Symbol shape and color represent different body sites and archaeal taxa, respectively. Symbols with black borders denote methanogens. GABA, γ-aminobutyric acid; TMA, trimethylamine; TMAO, trimethylamine N-oxide; 1°BA, primary bile acid; 2°BA, secondary bile acid. Descriptions of enzymes are available in Table S3. Detailed information of the presence of genes and those encoding hydrogenases and TCDB is available in Fig. S1 and S2 and Table S4, respectively.