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. 2022 Mar 22;10(2):e02294-21. doi: 10.1128/spectrum.02294-21

TABLE 2.

Predicted flavoproteins encoded in the chromosome II of Brucella ovis ATCC 25840

 Entry EC Protein Pfam domainsa Locus tag Protein code Flavin Coenzyme or Ligand More similar PDB (% identity)
46 1.1.2.3 L-lactate dehydrogenase (cytochrome c o b2) FMN_dh (PF01070) 14-377 BOV_RS14715 (lldD) ABQ62635.1 FMN   5ZBM (40)
47 1.1.-.-b Potential L-gulonolactone oxidase FAD-binding oxygen oxidoreductase c FAD_binding_4 (PF01565) 22-149 nothing up to 444 BOV_RS14405 ABQ62001.1 FAD   4AUT (34)
48 1.1.1.402 D-erythritol 1-phosphate dehydrogenase DAO (PF01266) 8-333 BOV_RS14450 (eryB) ABQ62056.1 FAD Quinone 2QCU (51)
DAO_C (PF16901) 386-482
49 1.1.99.1 Choline dehydrogenase (GMC family, membrane bound) GMC_oxred_N (PF00732) 5-295 BOV_RS14905 ABQ62100.1 FAD   4HA6 (34)
GMC_oxred_C (PF05199) 387-523
50 1.1.99.2 Predicted L-2-hydroxyglutarate dehydrogenase DAO (PF01266) 5-392 BOV_RS15155 (lhgO) ABQ62911.1 FAD NADH 3DME (37)
51 1.1.99.14 Glycolate dehydrogenase GlcD subunit FAD_binding_4 (PF01565) 55-193 BOV_RS11160 (glcD) ABQ62237.1 FAD   3PM9 (29)
FAD-oxidase_C (PF02913) 229-470
52 1.3.1.-b /1.7.1.B1 Predicted alkene reductase: N-ethylmaleimide reductase, glycerol trinitrate reductase or xenobiotic reductase B Oxidored_FMN (PF00724) 3-349 BOV_RS14625 ABQ62490.1 FMN NAD(P)H 5N6G (69)
53 1.3.8.-b Acyl-CoA dehydrogenase AidB_N (PF18158) 17-173 BOV_RS13205 ABQ62576.1 FAD   5EZ3 (100)
Acyl-CoA_dh_M (PF02770) 188-282
Acyl-CoA_dh_1 (PF00441) 292-447
54 1.3.8.-b Acyl-CoA dehydrogenase Acyl-CoA_dh_N (PF02771) 4-116 BOV_RS12330 ABQ62784.1 FAD   4N5F (63)
Acyl-CoA_dh_M (PF02770) 120-214
Acyl-CoA_dh_1 (PF00441) 227-375
55 1.3.8.-b Acyl-CoA dehydrogenase Acyl-CoA_dh_N (PF02771) 9-115 BOV_RS14135 ABQ62889.1 FAD   5LNX (36)
Acyl-CoA_dh_M (PF02770) 120-218
Acyl-CoA_dh_1 (PF00441) 231-378
56 1.3.8.-b Acyl-CoA dehydrogenase Acyl-CoA_dh_N (PF02771) 3-157 BOV_RS14115 ABQ62082.1 FAD   6IJC (61)
Acyl-CoA_dh_M (PF02770) 163-271
Acyl-CoA_dh_1 (PF00441) 282-451
Acyl-CoA_dh_C (PF12806) 467-593
57 1.3.99.-b Predicted KsdD-like steroid dehydrogenase FAD_binding_2 (PF00890) 5-533 BOV_RS13530 ABQ62061.1 FAD   1D4D (25)
58 1.4.1.13 Glutamate synthase large subunit (alpha subunit) GATase_2 (PF00310) 56-480 BOV_RS10585 (gltB) ABQ61996.1 FMN 3Fe-4S 1EA0 (45)
Glu_syn_central (PF04898) 508-794
Glu_synthase (PF01645) 856-1230
GXGXG (PF01493) 1309-1498
Glutamate synthase small subunit (beta subunit) Fer4_20 (PF14691) 24-131 BOV_RS10590 (gltD) ABQ62546.1 FAD NADPH 4Fe-4S 6S6U_G (37)
Pyr_redox_2 (PF07992) 148-465
59 1.4.99.-b D-amino acid dehydrogenase DAO (PF01266) 3-397 BOV_RS14735 (dadA) ABQ62278.1 FAD   4YSH (26)
60 1.4.-.-b Predicted D-amino acid dehydrogenase DAO (PF01266) 7-397 BOV_RS13345 ABQ62519.1 FAD 4YSH (26)
61 1.4.-.-b Predicted D-amino acid dehydrogenase DAO (PF01266) 34-384 BOV_RS13970 ABQ62405.1 FAD   4YSH (24)
62 1.5.3.1 Predicted monomeric Sarcosine oxidase DAO (PF01266) 31-383 BOV_RS13970 ABQ62932.1 FAD   1ZOV (22)
63 1.6.99.1 NADPH dehydrogenase (Old yellow enzyme) Oxidored_FMN (PF00724) 2-340 BOV_RS11390 ABQ62422.1 FMN NADPH 3GR7 (34)
64 1.6.-.-b NADH dehydrogenase Pyr_redox_2 (PF07992) 8-325 BOV_RS12460 ABQ62704.1 FAD NADH 4NWZ (31)
65 1.8.1.2 Assimilatory sulphite reductase (NADPH) alpha component cluster PepSY_TM (PF03929) (3-149) BOV_RS11420 WP_006015252.1     TM helices
Hypothetical protein (81aa) BOV_RS11425 WP_006015255.1      
PepSY_TM (PF03929) (2-128) BOV_RS11430 WP_006015257.1      
Flavodoxin_1 (PF00258) (74-147) FMN   6EFV (∼30 B. melitensis)
FAD_binding_6 (PF00970) (80-171) BOV_RS11435 WP_006015259.1 FAD  
NAD_binding_1 (PF00175) (189-291)   NADPH
66 1.8.1.4 Dihydrolipoyl dehydrogenase (lpdA-1) Pyr_redox_2 (PF07992) 7-326 BOV_RS12670 (lpdA-1) ABQ62466.1 FAD NAD(P)H 6CMZ (60)
Pyr_redox_dim (PF02852) 345-453
67 1.8.5.B1 Peptide-methionine (S)-S-oxide reductase (quinone) (Msr). MsrP catalytic subunit. MsrQ heme-binding subunit Ferric_reduct (PF01794) 55-166 BOV_RS15075 (msrQ) ABQ62365.1 FMN heme b 6HCY_A (17)
Oxidored_molyb (PF00174) 98-252 BOV_RS15070 (msrP) ABQ62343.1 Molybdopterin Quinone 1XDY (54)
68 1.13.11.32 Nitronate monooxygenase (formerly 2-nitropropane dioxygenase NPD) NMO (PF03060) 124-342 (formerly NPD) BOV_RS14290 ABQ62537.1 FMN   3BW2 (26)
69 1.13.11.79 Predicted aerobic 5,6-dimethylbenzimidazole synthase (BluB) Nitroreductase (PF00881) 74-240 BOV_RS15390 (bluB) ABQ62404.1 FMN NADH 2ISK (36)
70 1.14.13.-b UbiH/UbiF family hydroxylase FAD_binding_3 (PF01494) 49-377 BOV_RS13080 ABQ62553.1 FAD NAD(P) 5KOX_A (20)
71 1.14.13.2 4-hydroxybenzoate 3-monooxygenase FAD_binding_3 (PF01494) 2-342 BOV_RS13400 (pobA) ABQ62030.1 FAD NAD(P)H 1PBE (63)
72 1.18.1.3/5 Predicted Ferredoxin/rubredoxin/ putidaredoxin NAD+ Reductase 1: Pyr_redox_2 (PF07992) 4-301 BOV_RS13795 ABQ62051.1 FAD NADH 3FG2 (45)
2: Reductase_C (PF14759) 320-404
73 1.-.-.- b Predicted nitroreductase family protein Nitroreductase (PF00881) 48-216 BOV_RS12545 ABQ62091.1 FMN 2IFA (55)
74 2.7.7.2 Bifunctional riboflavin kinase/FAD synthase FAD_syn (PF06574) 18-172 BOV_RS11255 (ribF) ABQ62831.1 FMN & FAD   2X0K (36)
2.7.1.26 Flavokinase (PF01687) 190-313 RF & FMN
75 2.7.1.180 FAD:protein FMN transferase ApbE (PF02424) 18-296 BOV_RS11440 ABQ62066.1 FAD   5MGY (38) 6NXI (36)
76 2.7.13.3 Blue-light-activated histidine kinase PAS_9 (PF13426) 34-136 BOV_RS13160 ABQ62113.1 FMN   6PPS (100)
PAS_3 (PF08447) 184-259  
HWE_HK (PF07536) 285-367    
77 4.1.1.36 Coenzyme A biosynthesis bifunctional protein: Phosphopantothenoyl-cysteine decarboxylase/Phosphopantothenate–cysteine ligase (CTP) Flavoprotein (PF02441) 7-180 BOV_RS15430 (coaBC) ABQ62036.1 FMN   1E20 (34)
6.3.2.5 DFP (PF04127) 189-375 CTP 4QJI (42)
78 Protein NrdI Flavodoxin_NdrI (PF07972) 5-122 BOV_RS11810 (nrdI)  ABQ62891.1 FMN   2XOD (36)
a

Pfam domains include name, code, and residues in the B. ovis flavoprotein making the domain.

b

Identified as flavoenzyme, but available information does not allow to fully predict its activity.

c

Shown in bold and italics are those candidates for which a clear function cannot be depicted.