FIG 4.

Alterations in hippocampus and substantia nigra catecholamine profiles in antibiotic treated and C. difficile infected mice. Hippocampal catecholamine concentration in different treatment groups: (A) dopamine (DA), (B) its metabolite 3, 4-dihydroxyphenylacetic acid (DOPAC), and (C) norepinephrine (NE) levels. (Hippocampal HVA levels were below the detection limit in all groups); substantia nigra (SN) catecholamine concentration in different treatment groups: (D) dopamine (DA), (E) its metabolite 3,4-dihydroxyphenylacetic acid (DOPAC), (F) homovanillic acid (HVA), and (G) norepinephrine (NE) levels. n = 5. All data (A–G) are presented as the mean, and error bars indicate SEM. One-way ANOVA with adjusted P-value was used to test for statistical significance **P < 0.01, *P < 0.05.