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. Author manuscript; available in PMC: 2022 Apr 27.
Published in final edited form as: J Bone Miner Res. 2015 Jun;30(6):1064–1076. doi: 10.1002/jbmr.2433

Fig. 2.

Fig. 2.

Net catabolic effects of continuous PTH infusion in female control mice were blocked in female 0CNIgf1r−/− mice; the response in male mice differed. (A) Representative micro-CT 3D reconstructions of the secondary spongiosa of the distal femoral metaphysis in female and male continuously PTH- and vehicle-infused 0CNIgf1r−/− and control mice. (B) Quantitative analysis of trabecular bone in distal femurs from 16-week-old continuously PTH- and vehicle-infused 0CNIgf1r−/− and control mice with micro-CT (n=8–12). Tissue volume (mm3), bone volume (mm3), bone volume/tissue volume, connectivity density (1/mm3), trabecular number (1/mm), trabecular thickness (mm), trabecular separation (mm), and mineral content (HU/cm2) are shown. (C) Quantitative analysis of cortical bone in midshaft femurs from 16-week-old continuously PTH- and vehicle-infused 0CNIgf1r−/− and control mice with micro-CT (n=8–12). Cross-sectional area (mm2), cortical bone area (mm2), cortical area fraction, and cortical thickness (mm) are shown. Data are shown as mean ± SE; *p< 0.05.