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. Author manuscript; available in PMC: 2022 Apr 27.
Published in final edited form as: J Bone Miner Res. 2015 Jun;30(6):1064–1076. doi: 10.1002/jbmr.2433

Fig. 4.

Fig. 4.

Osteoblast stimulatory effects of continuous PTH were less robust when assessed in female control bone marrow stromal cell (BMSC) cultures and abrogated in those from female 0CNIgf1r−/− mice. (A) Quantitative analysis of alkaline phosphatase (ALP)+ colony-forming units (CFUs) at day 14 of BMSCs after 4-week in vivo exposure to continuous PTH or vehicle in 0CNIgf1r−/− and control mice (n=8–12). (B) Quantitative analysis of mineralization nodules at day 21 of bone marrow stromal cell cultures after 4-week in vivo exposure to continuous PTH or vehicle in 0CNIgf1r−/− and control mice (n=8–12). Data are shown as mean ± SE; *p< 0.05. (C) A representative bone marrow stromal cell culture image is displayed for alkaline phosphatase staining at 14 days and mineralization nodules at 21 days for continuously PTH- and vehicle-infused female and male 0CNIgf1r−/− and control mice (n=8–12).