Table 1.
Patients Characteristics at Diagnosis and Genes Mutation Profiles (n=206)
| Characteristic | Peritoneal Meta Only (n=15) | Liver Meta Only (n=145) | Lung Meta Only (n=46) | P value |
|---|---|---|---|---|
| Median age (years) | 65.0 (37–71) | 62.0 (26–90) | 65.5 (41–86) | 0.110 |
| Gender (M:F) | 11:4 | 90:55 | 20:26 | 0.041 |
| Primary tumor location | 0.191 | |||
| Right side | 7 | 36 | 13 | |
| Left side | 8 | 109 | 33 | |
| KRAS mutation | 3/12, 25.0% | 39/107, 36.4% | 12/33, 36.4% | 0.730 |
| NRAS mutation | 1/12, 8.3% | 6/82, 7.3% | 2/28, 7.1% | 0.991 |
| BRAF mutation | 2/13, 15.4% | 7/102, 6.9% | 1/35, 2.9% | 0.300 |
| EGFR over expression | 12/13, 92.3% | 76/85, 89.4% | 16/19, 84.2% | 0.741 |
| UGT1A1 mutant (*1/*28) | 4/15, 26.7% | 16/67, 23.9% | 6/26, 23.1% | 0.737 |
| PFS (months) | 18.0 | 18.2 | 26.6 | 0.194 |
| OS (months) | 24.6 | 25.0 | 44.5 | 0.191 |
Notes: Six TA repeats representing the most common allele of the UGT1A1 gene (UGT1A1*1, wild-type) and seven TA repeats representing a variant allele (UGT1A1*28, mutant type).
Abbreviations: EGFR, epidermal growth factor receptor; UGT1A1, uridine diphosphate glucuronosyI transferase 1A1; PFS, progression-free survival; OS, overall survival.