TABLE 3.

Numbers of surviving mice observed at 5 days in four groups with or without 48 h of antimicrobial therapy^a

Bacterial inoculum (CFU); no. of mice	No. of mice (%)b surviving at 5 days after treatment withc:
	CTX, 150 mg/kg, i.p. q6h	MIN, 20 mg/kg, i.p. q12h	CTX, 150 mg/kg, i.p. q6h + MIN, 20 mg/kg, i.p. q12h	Control
3.8 × 107; 10	0	6	10	0
3.9 × 107; 10	1	3	9	0
4.5 × 107; 12	2	5	10	0
Total	3 (9.4)	14 (43.8)	29 (90.6)	0 (0)

^aMice were infected by intraperitoneal (i.p.) injection of A. hydrophila A136. 

^bFor treatment with cefotaxime (CTX) versus treatment with minocycline (MIN), P = 0.001; for treatment with MIN versus treatment with CTX plus MIN, P < 0.0001; for treatment with CTX versus treatment with CTX plus MIN, P < 0.00001. 

^cq6h, every 6h; q12h, every 12 h.